Bioinformatics & Statistical Genetics
When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms.
The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.
- A New Method for Detecting Associations with Rare Copy-Number Variants. Copy number variants (CNVs) play an important role in the etiology of many diseases such as cancers and psychiatric disorders...
- Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. he identification of small molecules that target specific CFTR variants has ushered in a new era of treatment for cystic fibrosis (CF), yet optimal, individualized treatment of CF will require identification and targeting of disease modifiers.
- The projack: a resampling approach to correct for ranking bias in high-throughput studies The problem of ranked inference arises in a number of settings, for which the investigator wishes to perform parameter inference after ordering a set of m statistics.