Bioinformatics & Statistical Genetics
When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms.
The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.
- Roles of solvent accessibility and gene expression in modeling protein sequence evolution. A probabilistic framework for codon substitution that evaluates joint effects of relative solvent accessibility (RSA), a structural constraint; and gene expression, a functional constraint