Bioinformatics & Statistical Genetics
When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms.
The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.
- The projack: a resampling approach to correct for ranking bias in high-throughput studies The problem of ranked inference arises in a number of settings, for which the investigator wishes to perform parameter inference after ordering a set of m statistics.
- Prediction of human population responses to toxic compounds by a collaborative competition The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing
- mpact of Low Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study. Rodent and human studies suggest that early life BPA exposure may result in an anxious, hyperactive phenotype, but results are conflicting and data from studies using multiple doses below the no-observed-adverse-effect level (NOAEL) are limited.