Gene expression bias between the subgenomes of allopolyploid hybrids is an emergent property of the kinetics of expression
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Bioinformatics & Statistical Genetics
When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms. The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.
Recent Publications
- Gene expression bias between the subgenomes of allopolyploid hybrids is an emergent property of the kinetics of expression A long-standing puzzle in genetics has been cases where mating individuals of different lineages results in hybrid offspring whose forms are not simple intermediates between the two parents. A special case of such hybridizations are allopolyploidies, where genome doubling accompanies the hybridization. In newly formed allopolyploids, one of the contributing progenitor subgenomes generally expresses its genes at higher levels than does the other subgenome. It is believed that, as allopolyploids age, these expression differences drive differential duplicate gene losses between the subgenomes, as most older polyploidies have only a small proportion of their genes duplicated and show strong biases in which copies are lost. However, why the expression biases appear in the first place has been debated. Here, we use simple models of gene expression to show that the merging of distinct progenitor genomes through allopolyploidy will almost always yield expression biases due to the nonlinear kinetics of transcription. We argue that expression biases are hence the expectation for most allopolyploidies without a need for more complex explanations and that phenomena such as hybrid vigor may have similar origins.
- Whole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories
- Genomic map of candidate human imprint control regions: the imprintome
- A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes
- VIEW poly: a visualization tool to integrate and explore results of polyploid genetic analysis
- A new liver eQTL map from 1,183 individuals provides evidence for novel eQTLs of drug response, metabolic and sex-biased phenotypes.
News
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