Bioinformatics & Statistical Genetics

When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms. The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.

Recent Publications

• Entry of bunyaviruses into plants and vectors. The majority of plant-infecting viruses are transmitted by arthropod vectors that deliver them directly into a living plant cell... Chen Y, Dessau M, Rotenberg D, Rasmussen DA, Whitfield AE.
• PeakPass: Automating ChIP-Seq Blacklist Creation. ChIP-Seq blacklists contain genomic regions that frequently produce artifacts and noise in ChIP-Seq experiments. To improve signal-to-noise ratio, ChIP-Seq pipelines often remove data points that map to blacklist regions... Wimberley CE, Heber S.
• A new liver eQTL map from 1,183 individuals provides evidence for novel eQTLs of drug response, metabolic and sex-biased phenotypes. Expression quantitative trait locus (eQTL) studies in human liver are crucial for elucidating how genetic variation influences variability in disease risk and therapeutic outcomes and may help guide strategies to obtain maximal efficacy and safety of clinical interventions... Etheridge AS, Gallins PJ, Jima D, Broadaway KA, Ratain MJ, Schuetz E, Schadt E, Schroder A, Molony C, Zhou Y, Mohlke KL, Wright FA, Innocenti F.

News

Professor Benjamin Callahan to receive the ASM’s Microbiome Data Prize for 2023

Benjamin Callahan, BRC member and Associate Professor of Department of Population Health and Pathobiology, has been selected to receive the […]

1.26.2023