In fruit flies, infection results in increased genetic diversity
EPA awards grant for multi-institution collaboration between the BRC and Texas A&M
DREAMing of smart crowds in toxicity testing
Better, faster, stronger GWAS
New Project Tackles Genetic Switchboard for DNA

Bioinformatics & Statistical Genetics

When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms.

The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.

Recent Publications

  • No Evidence that Infection Alters Global Recombination Rate in House Mice. Recombination rate is a complex trait, with genetic and environmental factors shaping observed patterns of variation. Although recent studies have begun to unravel the genetic basis of recombination rate differences between organisms, less attention has focused on the environmental determinants of crossover rates. Dumont BL, Devlin AA, Truempy DM, Miller JC, Singh ND.
  • HABP2 Mutation and Nonmedullary Thyroid Cancer. The G534E variant of HABP2 could be the causative mutation in familial nonmedullary thyroid carcinoma. The genetic evidence included segregation of this heterozygous variant in a family with papillary thyroid cancer and a significant difference in the frequency of the mutation between patients with papillary thyroid cancer and persons with unknown disease status. Zhou EY, Lin Z, Yang Y.
  • Testing and estimation in marker-set association study using semiparametric quantile regression kernel machine. We consider quantile regression for partially linear models where an outcome of interest is related to covariates and a marker set (e.g., gene or pathway). Kong D, Maity A, Hsu FC, Tzeng JY.


The Bioinformatics Research Center was pleased to present the 2015 C. Clark Cockerham Guest Lecture, with guest speaker, Dr. Nancy […]