Bioinformatics & Statistical Genetics
When the BRC at NC State University was founded in 2000, it was with the understanding that quantitative methods applied to massive datasets are essential to the comprehension of the genomic structure of even the simplest organisms.
The university is located in Raleigh, the heart of one of the leading research areas in the United States. The BRC has developed strong relationships with industrial partners and other academic or government organizations in the Research Triangle Park area.
- Sporadic, Global Linkage Disequilibrium between Unlinked Segregating Sites. Demographic, genetic, or stochastic factors can lead to perfect linkage disequilibrium (LD) between alleles at two loci without respect to the extent of their physical distance, a phenomenon that Lawrence et. al. refer to as "genetic indistinguishability".
- Improving outpatient implementation of preexposure prophylaxis in men who have sex with men. Preexposure prophylaxis (PrEP) has been shown to decrease the transmission of human immunodeficiency virus (HIV) when used in high-risk populations including men who have sex with men.
- Expression and Localization of CaBP Ca2+ Binding Proteins in the Mouse Cochlea. CaBP1 and CaBP2 may have overlapping roles in regulating Ca2+ signaling in the hair cells, and CaBP1 may have an additional function in the spiral ganglion...