Bio

Alon Greenbaum joined NC State in January 2019 as a Chancellor’s Faculty Excellence Program cluster hire in High-dimensional Integration of Biological Systems. An assistant professor in the joint UNC-CH/NC State Department of Biomedical Engineering, Greenbaum develops complex imaging devices and algorithms to advance three-dimensional profiling of intact organs to answer biological questions regarding aging and disease progression. Application areas will span the development of adaptive light-sheet microscopes and algorithms for rapid high-resolution imaging of whole organisms; computational tools to handle big–data; and translational applications, such as exploration of rare stem-cell niches in the context of age-associated diseases.

Publications

• Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae , iScience (2025)
• A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research , Frontiers in Genome Editing (2024)
• Intelligent Beam Optimization for Light-Sheet Fluorescence Microscopy through Deep Learning , Intelligent Computing (2024)
• Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis , American Journal of Respiratory Cell and Molecular Biology (2024)
• Roadmap on computational methods in optical imaging and holography [invited] , Applied Physics B (2024)
• Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs , Frontiers in Pharmacology (2024)
• Assessment of drug permeability through an ex vivo porcine round window membrane model , iScience (2023)
• Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain , iScience (2023)
• COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains , Cell Reports Methods (2023)
• Deep learning-based adaptive optics for light sheet fluorescence microscopy , Biomedical Optics Express (2023)