Adverse drug reactions triggered by the common HLA-B*57:01 variant: a molecular docking study

New computer models from North Carolina State University show how a variant of a common protein involved in human immune response binds to the antiviral drug abacavir, causing a severe reaction known as the abacavir hypersensitivity syndrome (AHS). The work has implications for Personalized Medicine by predicting adverse reactions caused by existing drugs and future drug candidates in sub-populations of patients.
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