Recently the BRC was featured on both the College of Sciences website and the main NC State University website for the groundbreaking work being done through the Bioinformatics cluster.
The Bioinformatics cluster is part of NC State’s groundbreaking Chancellor’s Faculty Excellence Program, which aims to put faculty together, both physically and intellectually, to combine ideas and experience in ways that solve big problems. Faculty clusters and interdisciplinary work have become hot topics in higher education around the world, but this “new” interdisciplinary approach has actually permeated science for centuries. NC State’s program, focusing on assembling groups of faculty with complementary areas of expertise to study interdisciplinary research challenges, was one of the first major initiatives Chancellor Randy Woodson announced after coming to the university in 2010.
To read the article in its entirety, please visit the College of Sciences website here: https://sciences.ncsu.edu/news/the-proximity-principle
The Bioinformatics Research Center will be hosting weekly Industry and Government partners in informal talks aimed at partnership, collaboration, and the sharing of ideas. Each Monday at 11:30am, we will welcome a different partner to speak to our Graduate students, faculty and research staff. Talks last roughly 30 minutes, and are followed by pizza. Schedule is as follows:
Drs. Pierce (Chemistry), Fourches (Chemistry, BRC), and Elfenbein (CVM) have received a grant from the Research and Innovation Funding (RISF) program. Their research project is entitled “Development of Novel Therapeutics to Modulate Bacterial Biofilms” and will be conducted in 2016.
The Environmental Protection Agency (EPA) has awarded a 3-year grant to fund a collaboration between Oregon State University (Robert Tanguay, Jane La Du, Mike Simonich, Chris Sullivan) and North Carolina State University (David Reif) entitled “System Toxicological Approaches to Define Flame Retardant Adverse Outcome Pathways”.
From the EPA webpage:
A team of researchers from Oregon State University and North Carolina State University proposes to conduct the first comprehensive in vivo,structure-activity based toxicity studies of flame retardant chemicals (FRCs), including FRCs that EPA has phased out, FRCs that companies manufacture now, and FRCs that companies have proposed as replacements. (They) will test the hypothesis that the toxicity of FRCs will be highly dependent on their chemical structure.
Growing experimental evidences suggest the existence of direct relationships between the surface chemistry of nanomaterials and their biological effects. Herein, we have employed computational approaches to design a set of biologically active carbon nanotubes (CNTs) with controlled protein binding and cytotoxicity. Quantitative structure–activity relationship (QSAR) models were built and validated using a dataset of 83 surface-modified CNTs. A subset of a combinatorial virtual library of 240 000 ligands potentially attachable to CNTs was selected to include molecules that were within the chemical similarity threshold with respect to the modeling set compounds. QSAR models were then employed to virtually screen this subset and prioritize CNTs for chemical synthesis and biological evaluation. Ten putatively active and 10 putatively inactive CNTs decorated with the ligands prioritized by virtual screening for either protein-binding or cytotoxicity assay were synthesized and tested. We found that all 10 putatively inactive and 7 of 10 putatively active CNTs were confirmed in the protein-binding assay, whereas all 10 putatively inactive and 6 of 10 putatively active CNTs were confirmed in the cytotoxicity assay. This proof-of-concept study shows that computational models can be employed to guide the design of surface-modified nanomaterials with the desired biological and safety profiles.
Authors: Denis Fourches, Dongqiuye Pu, Liwen Li, Hongyu Zhou, Qingxin Mu, Gaoxing Su, Bing Yan & Alexander Tropsha